The door to Mausoleum / Gehenna is not affected. Sacrifice Room spikes still work, though the heart has to go on the spikes instead of Isaac. Spikes, Curse Room doors and Spiked Chests do no damage.During The Guardian (challenge #30), Devil Beggars and Blood Donation Machines deal damage to Isaac.Blood Donation Machines and Devil Beggars can be used for free.Eyes and other similar enemies, however, will still target Isaac. Most enemies now target the heart instead of Isaac. ![]()
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